Synthesis and Evaluation of AlgNa-g-poly(QCL-co-HEMA) Hydrogels as Platform for Chondrocyte Proliferation and Controlled Release of Betamethasone

Hydrogels obtained from combining different polymers are an interesting strategy for developing controlled release system platforms and tissue engineering scaffolds. In this study, the applicability of sodium alginate-g-(QCL-co-HEMA) hydrogels these biomedical applications was evaluated. were synthesized by free-radical polymerization using a concentration components. The characterized Fourier transform-infrared spectroscopy, scanning electron microscopy, swelling degree. Betamethasone as well in vitro cytocompatibility with chondrocytes fibroblast cells also Scanning microscopy confirmed porous surface morphology all cases. percent determined at pH observed to be pH-sensitive. behavior betamethasone matrices investigated PBS media (pH = 7.4) drug released manner up 8 h. Human fibroblasts cultured on hydrogels. MTS assay showed that almost cytocompatibles increase proliferation both cell types after one week incubation Live/Dead® assay. These results demonstrate attractive materials pharmaceutical due their characteristics, kinetics, biocompatibility.